Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/11651
Title: Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system
Authors: Milić, Dragan 
Kop T.
Csanadi J.
Juranic Z.
Zizak Z.
Gasic M.
Solaja B.
Issue Date: 4-Nov-2009
Journal: Steroids
Abstract: A simple approach to a stable steroidal estrone derived A,B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac2O-TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the antiproliferative activity of the spiro-product against three cancer cell lines, are also presented. © 2009 Elsevier Inc. All rights reserved.
URI: https://open.uns.ac.rs/handle/123456789/11651
ISSN: 0039128X
DOI: 10.1016/j.steroids.2009.06.002
Appears in Collections:POLJF Publikacije/Publications

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