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https://open.uns.ac.rs/handle/123456789/11651
Title: | Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system | Authors: | Milić, Dragan Kop T. Csanadi J. Juranic Z. Zizak Z. Gasic M. Solaja B. |
Issue Date: | 4-Nov-2009 | Journal: | Steroids | Abstract: | A simple approach to a stable steroidal estrone derived A,B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac2O-TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the antiproliferative activity of the spiro-product against three cancer cell lines, are also presented. © 2009 Elsevier Inc. All rights reserved. | URI: | https://open.uns.ac.rs/handle/123456789/11651 | ISSN: | 0039128X | DOI: | 10.1016/j.steroids.2009.06.002 |
Appears in Collections: | POLJF Publikacije/Publications |
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