Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system

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Назив:	Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system
Аутори:	Milić, Dragan Kop T. Csanadi J. Juranic Z. Zizak Z. Gasic M. Solaja B.
Датум издавања:	4-нов-2009
Часопис:	Steroids
Сажетак:	A simple approach to a stable steroidal estrone derived A,B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac2O-TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the antiproliferative activity of the spiro-product against three cancer cell lines, are also presented. © 2009 Elsevier Inc. All rights reserved.
URI:	https://open.uns.ac.rs/handle/123456789/11651
ISSN:	0039128X
DOI:	10.1016/j.steroids.2009.06.002
Налази се у колекцијама:	POLJF Publikacije/Publications