3α,7α-dihydroxy-12-oxo-5β-cholanate as blood-brain barrier permeator

Abstract

The aim of the study was to test the efficacy of 3α,7α-dihydroxy-12-oxo-5β-cholanate as a blood-brain barrier (BBB) permeator by examining its effect on quinine uptake into the central nervous system in rats, analgesic action of morphine, and on the sleeping time induced by pentobarbital. The obtained results indicate that sodium 3α,7α-dihydroxy- 12-oxo-5β -cholanate can be considered as modifier of BBB permeability, as it exhibited a promoting effect in all three tests. In the test of quinine uptake, methyl ester of 3α,7α-dihydroxy-12-oxo-5β -cholanoic acid (included in the study for comparison) did not show a promoting effect, which can suggest its specific action. Copyright © 2004 by Institute of Pharmacology Polish Academy of Sciences.