Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/11248
DC FieldValueLanguage
dc.contributor.authorMomir Mikoven_US
dc.contributor.authorSlavko Kevrešanen_US
dc.contributor.authorKsenija Kuhajdaen_US
dc.contributor.authorVida Jakovljevićen_US
dc.contributor.authorVelibor Vasovićen_US
dc.date.accessioned2020-03-03T14:43:35Z-
dc.date.available2020-03-03T14:43:35Z-
dc.date.issued2004-01-01-
dc.identifier.issn12306002en_US
dc.identifier.urihttps://open.uns.ac.rs/handle/123456789/11248-
dc.description.abstractThe aim of the study was to test the efficacy of 3α,7α-dihydroxy-12-oxo-5β-cholanate as a blood-brain barrier (BBB) permeator by examining its effect on quinine uptake into the central nervous system in rats, analgesic action of morphine, and on the sleeping time induced by pentobarbital. The obtained results indicate that sodium 3α,7α-dihydroxy- 12-oxo-5β -cholanate can be considered as modifier of BBB permeability, as it exhibited a promoting effect in all three tests. In the test of quinine uptake, methyl ester of 3α,7α-dihydroxy-12-oxo-5β -cholanoic acid (included in the study for comparison) did not show a promoting effect, which can suggest its specific action. Copyright © 2004 by Institute of Pharmacology Polish Academy of Sciences.en_US
dc.language.isoenen_US
dc.relation.ispartofPolish Journal of Pharmacologyen_US
dc.subjectblood-brain barrieren_US
dc.subjectratsen_US
dc.subjectBile Acids and Saltsen_US
dc.title3α,7α-dihydroxy-12-oxo-5β-cholanate as blood-brain barrier permeatoren_US
dc.typeArticleen_US
dc.identifier.pmid56-
dc.identifier.scopus2-s2.0-3542993842-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/3542993842-
dc.description.versionPublisheden_US
dc.relation.lastpage371en_US
dc.relation.firstpage367en_US
dc.relation.issue3en_US
dc.relation.volume56en_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
crisitem.author.deptMedicinski fakultet, Katedra za farmakologiju i toksikologiju-
crisitem.author.parentorgMedicinski fakultet-
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