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https://open.uns.ac.rs/handle/123456789/10378
Title: | Correlation of HER-2/neu protein overexpression with other prognostic and predictive factors in invasive ductal breast cancer | Authors: | Tatjana Ivković Kapicl Slavica Knežević Ušaj Dragana Đilas-Ivanović Milana Panjković |
Keywords: | breast neoplasms;invasive ductal carcinoma;receptor, erbB-2;HER-2 proto-oncogene protein;imunohistochemistry | Issue Date: | 1-Jul-2007 | Journal: | In Vivo | Abstract: | Background: The objective of our study was to investigate the association between Her-2/neu status and other clinicopathological characteristics of ductal breast carcinoma. Patients and Methods: A total of 120 cases of breast carcinoma were included in this study. The immunohistochemical staining for HER-2/neu, hormone receptors, p53 and Ki-67 were evaluated. Results: HER-2/neu protein overexpression was present in 4 out of 63 T1 lesions, in 13 out of 44 T2 lesions, in 3 out of 7 T3 lesions, and in 3 out of 6 T4 lesions. Protein overexpression was found in 10 out of 21 grade III tumors and 13 out of 72 grade II tumors. Overexpression was not detected in grade I tumors. Of the 23 Her-2/Neu-positive cases, ER- and PR-negative status was detected in 61% and 69%, respectively. Her-2 protein overexpression was seen in 23 out of 93 high Ki-67 tumors, whereas overexpression was not detected in low Ki-67 cases. Conclusion: Statistically significant correlation was found between HER-2/neu protein overexpression and large tumour size, high histological grade, ER and PR negativity, and high Ki-67 proliferative index. | URI: | https://open.uns.ac.rs/handle/123456789/10378 | ISSN: | 0258851X |
Appears in Collections: | MDF Publikacije/Publications |
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