Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/10378
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tatjana Ivković Kapicl | en_US |
dc.contributor.author | Slavica Knežević Ušaj | en_US |
dc.contributor.author | Dragana Đilas-Ivanović | en_US |
dc.contributor.author | Milana Panjković | en_US |
dc.date.accessioned | 2020-03-03T14:39:11Z | - |
dc.date.available | 2020-03-03T14:39:11Z | - |
dc.date.issued | 2007-07-01 | - |
dc.identifier.issn | 0258851X | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/10378 | - |
dc.description.abstract | Background: The objective of our study was to investigate the association between Her-2/neu status and other clinicopathological characteristics of ductal breast carcinoma. Patients and Methods: A total of 120 cases of breast carcinoma were included in this study. The immunohistochemical staining for HER-2/neu, hormone receptors, p53 and Ki-67 were evaluated. Results: HER-2/neu protein overexpression was present in 4 out of 63 T1 lesions, in 13 out of 44 T2 lesions, in 3 out of 7 T3 lesions, and in 3 out of 6 T4 lesions. Protein overexpression was found in 10 out of 21 grade III tumors and 13 out of 72 grade II tumors. Overexpression was not detected in grade I tumors. Of the 23 Her-2/Neu-positive cases, ER- and PR-negative status was detected in 61% and 69%, respectively. Her-2 protein overexpression was seen in 23 out of 93 high Ki-67 tumors, whereas overexpression was not detected in low Ki-67 cases. Conclusion: Statistically significant correlation was found between HER-2/neu protein overexpression and large tumour size, high histological grade, ER and PR negativity, and high Ki-67 proliferative index. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | In Vivo | en_US |
dc.subject | breast neoplasms | en_US |
dc.subject | invasive ductal carcinoma | en_US |
dc.subject | receptor, erbB-2 | en_US |
dc.subject | HER-2 proto-oncogene protein | en_US |
dc.subject | imunohistochemistry | en_US |
dc.title | Correlation of HER-2/neu protein overexpression with other prognostic and predictive factors in invasive ductal breast cancer | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.pmid | 21 | - |
dc.identifier.scopus | 2-s2.0-34547793066 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/34547793066 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 678 | en_US |
dc.relation.firstpage | 673 | en_US |
dc.relation.issue | 4 | en_US |
dc.relation.volume | 21 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet, Katedra za patologiju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za patologiju | - |
crisitem.author.orcid | 0000-0003-4249-9260 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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