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https://open.uns.ac.rs/handle/123456789/11933
Nаziv: | Retention data from reverse-phase high-performance thin-layer chromatography in characterization of some bis-salicylic acid derivatives | Аutоri: | Đaković-Sekulić, Tatjana Perišić-Janjić N. Djurendi E. |
Dаtum izdаvаnjа: | 5-окт-2009 | Čаsоpis: | Biomedical Chromatography | Sažetak: | The chromatographic behaviour of salicylic acid derivatives was investigated using reversed-phase high performance thin-layer chromatography (RP HPTLC) with methanol-water and dioxane-water binary mixtures as mobile phase in order to establish relationships between chromatographic data and selected physico-chemical parameters that are related to ADME (absorption, distribution, metabolism and elimination). Some of the investigated compounds were screened for antioxidant activity. Examination of chromatographic behaviour revealed a linear correlation between RM values and the volume fraction of mobile phase modifier. Obtained RM0 values were correlated with lipophilicity, solubility, human intestinal absorption, plasma-protein binding, and blood-brain barrier data. The comparison among chromatographic data obtained by two mobile phase was performed with a statistical technique, principle component analysis. Copyright © 2009 John Wiley & Sons, Ltd. | URI: | https://open.uns.ac.rs/handle/123456789/11933 | ISSN: | 02693879 | DOI: | 10.1002/bmc.1200 |
Nаlаzi sе u kоlеkciјаmа: | PMF Publikacije/Publications |
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