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|Title:||Retention data from reverse-phase high-performance thin-layer chromatography in characterization of some bis-salicylic acid derivatives||Authors:||Djaković-Sekuli T.
|Issue Date:||5-Oct-2009||Journal:||Biomedical Chromatography||Abstract:||The chromatographic behaviour of salicylic acid derivatives was investigated using reversed-phase high performance thin-layer chromatography (RP HPTLC) with methanol-water and dioxane-water binary mixtures as mobile phase in order to establish relationships between chromatographic data and selected physico-chemical parameters that are related to ADME (absorption, distribution, metabolism and elimination). Some of the investigated compounds were screened for antioxidant activity. Examination of chromatographic behaviour revealed a linear correlation between RM values and the volume fraction of mobile phase modifier. Obtained RM0 values were correlated with lipophilicity, solubility, human intestinal absorption, plasma-protein binding, and blood-brain barrier data. The comparison among chromatographic data obtained by two mobile phase was performed with a statistical technique, principle component analysis. Copyright © 2009 John Wiley & Sons, Ltd.||URI:||https://open.uns.ac.rs/handle/123456789/11933||ISSN:||02693879||DOI:||10.1002/bmc.1200|
|Appears in Collections:||Naučne i umetničke publikacije|
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