Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/9760
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pósa M. | en |
dc.contributor.author | Guzvanj (Guzsvány), V. | en |
dc.contributor.author | Csanádi J. | en |
dc.contributor.author | Borbás J. | en |
dc.contributor.author | Gaál F. | en |
dc.date.accessioned | 2020-03-03T14:34:27Z | - |
dc.date.available | 2020-03-03T14:34:27Z | - |
dc.date.issued | 2009-12-01 | en |
dc.identifier.issn | 13180207 | en |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/9760 | - |
dc.description.abstract | 12-Monoketocholic acid (12-MKC) shows a promotive effect in the transport of some drugs (lidocaine, morphine, quinine, gliclazide, etc.). In the mechanism of pharmacological action of 12-MKC an important role plays its aggregation (self-association), as well as formation of mixed micelles. These phenomena were studied by the 1H NMR spin-lattice relaxation method using solutions of sodium salt of 12-MKC in D2O and in D2O solution saturated with 1-octanol. The function describing the dependence of the spin-lattice relaxation time (T1) on the concentration of Na-12-MKC (cBA) in D2O has one inflexion point (at the concentration of 48 mM), whereas the same function for the saturated solution of 1-octanol has two inflexion points (one at the concentration of 45 mM and the other at 87 mM). These differences in the curves T1 = f(cBA), as well as the shift of the solubilization curve of lecithin in the presence of 1-octanol towards higher concentrations of Na-12-MKC, indicate that sodium salt of this keto-bile acid forms mixed micelles with 1-ocatnol, so that the application of the micellar solution of Na-12-MKC in the presence of 1-octanol decreases membrane toxicity (membrane lysis) of this bile acid. The curves T1 = f(cBA) for methyl esters of 12-MKC and cholic acid in the CDCl3 solution have one inflexion point at the concentration above 5 mM, indicating formation of the micelles of Small's type, whereas methyl ester of 3,7,12-triketocholic acid forms a gel-like structure. | en |
dc.relation.ispartof | Acta Chimica Slovenica | en |
dc.title | Study of association of 12-Monoketocholic acid by <sup>1</sup>H NMR relaxation method | en |
dc.type | Journal/Magazine Article | en |
dc.identifier.scopus | 2-s2.0-74849124392 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/74849124392 | en |
dc.relation.lastpage | 814 | en |
dc.relation.firstpage | 807 | en |
dc.relation.issue | 4 | en |
dc.relation.volume | 56 | en |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Prirodno-matematički fakultet, Departman za hemiju, biohemiju i zaštitu životne sredine | - |
crisitem.author.parentorg | Prirodno-matematički fakultet | - |
Appears in Collections: | PMF Publikacije/Publications |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.