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https://open.uns.ac.rs/handle/123456789/9668
Nаziv: | Semisynthetic bile acids: a new therapeutic option for metabolic syndrome | Аutоri: | Lazarević, Slavica Đanić, Maja Goločorbin-Kon, Svetlana Al-Salami, Hani Mikov, Momir |
Ključnе rеči: | 24-nor-ursodeoxycholic acid (PubChem CID:22845702);3,7-dihydroxy-12-oxocholanoic acid (PubChem CID: 94235);Bile acid;Chemical compounds studied in this article obeticholic acid (PubChem CID: 447715);Diabetes;Dyslipidemia;FXR;INT-767 (PubChem CID: 23712772);INT-777 (PubChem CID: 45483949);Metabolic syndrome;TGR5 | Dаtum izdаvаnjа: | 2019 | Čаsоpis: | Pharmacological research | Sažetak: | Bile acids are endogenous emulsifiers synthesized from cholesterol having a peculiar amphiphilic structure. Appreciation of their beneficial effects on human health, recognized since ancient times, has expanded enormously since the discovery of their role as signaling molecules. Activation of farnesoid X receptor (FXR) and Takeda G-protein receptor-5 (TGR5) signaling pathways by bile acids, regulating glucose, lipid and energy metabolism, have become attractive avenue for metabolic syndrome treatment. Therefore, extensive effort has been directed into the research and synthesis of bile acid derivatives with improved pharmacokinetic properties and high potency and selectivity for these receptors. Minor modifications in the structure of bile acids and their derivatives may result in fine-tuning modulation of their biological functions, and most importantly, in an evasion of undesired effect. A great number of semisynthetic bile acid analogues have been designed and put in preclinical and clinical settings. Obeticholic acid (INT-747) has achieved the biggest clinical success so far being in use for the treatment of primary biliary cholangitis. This review summarizes and critically evaluates the key chemical modifications of bile acids resulting in development of novel semisynthetic derivatives as well as the current status of their preclinical and clinical evaluation in the treatment of metabolic syndrome, an aspect that is so far lacking in the scientific literature. Taking into account the balance between therapeutic benefits and potential adverse effects associated with specific structure and mechanism of action, recommendations for future studies are proposed. | URI: | https://open.uns.ac.rs/handle/123456789/9668 | ISSN: | 10436618 | DOI: | 10.1016/j.phrs.2019.104333 |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
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