Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/9663
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Armin Mooranian | en_US |
dc.contributor.author | Nassim Zamani | en_US |
dc.contributor.author | Giuseppe Luna | en_US |
dc.contributor.author | Hesham Al-Sallami | en_US |
dc.contributor.author | Momir Mikov | en_US |
dc.contributor.author | Svetlana Goločorbin-Kon | en_US |
dc.contributor.author | Goran Stojanović | en_US |
dc.contributor.author | Frank Arfuso | en_US |
dc.contributor.author | Božica Kovačević | en_US |
dc.contributor.author | Hani Al-Salami | en_US |
dc.date.accessioned | 2020-02-05T20:41:49Z | - |
dc.date.available | 2020-02-05T20:41:49Z | - |
dc.date.issued | 2019-11-26 | - |
dc.identifier.issn | 10837450 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/9663 | - |
dc.description.abstract | Studies in our laboratory have shown potential applications of the anti-atherosclerotic drug probucol (PB) in diabetes due to anti-inflammatory and β-cell protective effects. The anti-inflammatory effects were optimized by incorporation of the anti-inflammatory bile acid, ursodeoxycholic acid (UDCA). This study aimed to test PB absorption, tissue accumulation profiles, effects on inflammation and type 1 diabetes prevention when combined with UDCA. Balb/c mice were divided into three equal groups and gavaged daily PB powder, PB microcapsules or PB-UDCA microcapsules for one week, at a constant dose. Mice were injected with a single dose of intraperitoneal/subcutaneous alloxan to induce type-1 diabetes and once diabetes was confirmed, treatments were continued for 3 days. Mice were euthanized and blood and tissues collected for analysis of PB and cytokine levels. The PB-UDCA group showed the highest PB concentrations in blood, gut, liver, spleen, brain, and white adipose tissues, with no significant increase in pancreas, heart, skeletal muscles, kidneys, urine or feces. Interferon gamma in plasma was significantly reduced by PB-UDCA suggesting potent anti-inflammatory effects. Blood glucose levels remained similar after treatments, while survival was highest among the PB-UDCA group. Our findings suggest that PB-UDCA resulted in best PB blood and tissue absorption and reduced inflammation. | en_US |
dc.language.iso | en | en_US |
dc.relation | Cost-effective microfluidic electronic devices for optimal drug administration based on fractional pharmacokinetics for leukemia treatments | en_US |
dc.relation.ispartof | Pharmaceutical Development and Technology | en_US |
dc.subject | diabetes mellitus type 1 | en_US |
dc.subject | ursodeoxycholic acid | en_US |
dc.subject | bile acids | en_US |
dc.subject | nanoencapsulation technology | en_US |
dc.subject | probucol | en_US |
dc.title | Bile acid-polymer-probucol microparticles: protective effect on pancreatic β-cells and decrease in type 1 diabetes development in a murine model | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1080/10837450.2019.1665069 | - |
dc.identifier.pmid | 24 | - |
dc.identifier.scopus | 2-s2.0-85073987795 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85073987795 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 1277 | en_US |
dc.relation.firstpage | 1272 | en_US |
dc.relation.issue | 10 | en_US |
dc.relation.volume | 24 | en_US |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Departman za energetiku, elektroniku i telekomunikacije | - |
crisitem.author.dept | Institut za nizijsko šumarstvo i životnu sredinu | - |
crisitem.author.orcid | https://orcid.org/0000-0002-9257-8074 | - |
crisitem.author.orcid | 0000-0003-2098-189X | - |
crisitem.author.orcid | 0000-0002-9125-0659 | - |
crisitem.author.parentorg | Fakultet tehničkih nauka | - |
crisitem.author.parentorg | Univerzitet u Novom Sadu | - |
crisitem.project.grantno | H2020 MEDLEM | - |
crisitem.project.projectURL | http://medlemproject.com | - |
Appears in Collections: | FTN Publikacije/Publications ILFE Publikacije/Publications |
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