Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/9322
Title: | Probiotics - Interactions with Bile Acids and Impact on Cholesterol Metabolism | Authors: | Nebojša Pavlović Karmen Stankov Momir Mikov |
Keywords: | Probiotics;Bile acids;Cholesterol;Bile salt hydrolase;Interactions | Issue Date: | 1-Dec-2012 | Journal: | Applied Biochemistry and Biotechnology | Abstract: | The use of probiotics, alone or in interaction with bile acids, is a modern strategy in the prevention and treatment of hypercholesterolemia. Numerous mechanisms for hypocholesterolemic effect of probiotics have been hypothesized, based mostly on in vitro evidence. Interaction with bile acids through reaction of deconjugation catalyzed by bile salt hydrolase enzymes (BSH) is considered as the main mechanism of cholesterol-lowering effects of probiotic bacteria, but it has been reported that microbial BSH activity could be potentially detrimental to the human host. There are several approaches for prevention of possible side effects associated with BSH activity, which at the same time increase the viability of probiotics in the intestines and also in food matrices. The aim of our study was to summarize present knowledge of probiotics - bile acids interactions, with special reference to cholesterol-lowering mechanisms of probiotics, and to report novel biotechnological approaches for increasing the pharmacological benefits of probiotics. © 2012 Springer Science+Business Media New York. | URI: | https://open.uns.ac.rs/handle/123456789/9322 | ISSN: | 2732289 | DOI: | 10.1007/s12010-012-9904-4 |
Appears in Collections: | MDF Publikacije/Publications |
Show full item record
SCOPUSTM
Citations
86
checked on May 10, 2024
Page view(s)
31
Last Week
9
9
Last month
0
0
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.