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https://open.uns.ac.rs/handle/123456789/9158
Title: | Treatment results of childhood acute myeloid leukemia in Serbia | Authors: | Nada K. Milos K. Dragana V. Lidija D. Dragan, Milošević Knežević, Bojana Kraljačić, Dejan Nikolaj Jelena L. Ankica J. Milena J. Nada K. Gordana K. Predrag R. Dragana J. |
Issue Date: | 1-Feb-2013 | Journal: | Memo - Magazine of European Medical Oncology | Abstract: | We present the results of a retrospective study of acute myeloid leukemia (AML) treatment in Serbia in the period 2000-2012. Treatment was performed in four centers, two of which were located in Belgrade, one in Nis, and one in Novi Sad. Children affected by non-acute promyelocytic leukemia (non-APL) subtypes received treatment regimens derived from protocols of Berlin Frankfurt Munster AML study group, whereas children with APL were treated according to the AIEOP/GIMEMA ATRA plus Idarubicin "AIDA" protocol. Total number of patients was 106, out of whom 48 were girls (45.3 %) and 58 boys (54.7 %); median age at diagnosis was 9.0 years (range 1 month-17.9 years). In total, 82.1 % of patients achieved complete remission after induction treatment. Twelve patients (11.3 %) died during induction, before achieving complete remission; there were nine deaths during remission (10.5 %) and 20 patients relapsed (23.2 %). Median time of follow-up was 54 months. Two patients (1.9 %) were lost to follow-up. Event-free survival was 50.3 % and overall survival was 58.9 %. © 2012 Springer-Verlag Wien. | URI: | https://open.uns.ac.rs/handle/123456789/9158 | ISSN: | 18655041 | DOI: | 10.1007/s12254-012-0051-y |
Appears in Collections: | PMF Publikacije/Publications |
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