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https://open.uns.ac.rs/handle/123456789/8628
Nаziv: | Ultrastructural characteristics of the vascular wall components of ruptured atherosclerotic abdominal aortic aneurysm | Аutоri: | Irena Tanasković Vesna Lačković D. Radak Slavica Knežević Ušaj Milena Lačković Vesna Stanković Maja Vulović Lidija Poček V. Kanjuh |
Ključnе rеči: | Ruptured aneurysm wall;foam cells;plaque;smooth muscle cells | Dаtum izdаvаnjа: | 2-окт-2013 | Čаsоpis: | Archives of Biological Sciences | Sažetak: | The aim of this study was to determine the ultrastructural characteristics of cell populations and extracellular matrix components in the wall of ruptured atherosclerotic abdominal aortic aneurysm (AAA). We analyzed 20 samples of ruptured AAA. For orientation to the light microscopy, we used routine histochemical techniques by standard procedures. For ultrastructural analysis, we applied transmission electron microscopy (TEM). Our results have shown that ruptured AAA is characterized by the remains of an advanced atherosclerotic lesion in the intima followed by a complete absence of endothelial cells, the disruption of basal membrane and disruption of internal elastic lamina. On plaque margins as well as in the inner media we observed smooth muscle cells (SMCs) that posses a euchromatic nucleus, a well-developed granulated endoplasmic reticulum around the nucleus and reduced myofilaments. The remains of the ruptured lipid core were acellular in all samples; however, on the lateral sides of ruptured plaque we observed a presence of two types of foam cells (FCs), spindle- and star-shaped. Fusiform FCs possess a well-differentiated basal lamina, caveolae and electron dense bodies, followed by a small number of lipid droplets in the cytoplasm. Star-shaped FCs contain a large number of lipid droplets and do not possess basal lamina. On the inner margins of the plaque, we observed a large number of cells undergoing apoptosis and necrosis, extracellular lipid droplets as well as a large number of lymphocytes. The media was thinned out with disorganized elastic lamellas, while the adventitia exhibited leukocyte infiltration. The presented results suggest that atherosclerotic plaque in ruptured AAA contains vascular SMC synthetic phenotype and two different types of FCs: some were derived from monocyte/macrophage lineage, while others were derived from SMCs of synthetic phenotype. The striking plaque hypocellularity was the result of apoptosis and necrosis of different cell populations. | URI: | https://open.uns.ac.rs/handle/123456789/8628 | ISSN: | 3544664 | DOI: | 10.2298/ABS1304271T |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
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