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https://open.uns.ac.rs/handle/123456789/8428
Title: | Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells | Authors: | Pejin B. Iodice C. Bogdanović G. Kojić, Vesna Tešević V. |
Issue Date: | 1-Feb-2017 | Journal: | Arabian Journal of Chemistry | Abstract: | © 2013 The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 μg/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 μg/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs. | URI: | https://open.uns.ac.rs/handle/123456789/8428 | ISSN: | 18785352 | DOI: | 10.1016/j.arabjc.2013.03.003 |
Appears in Collections: | MDF Publikacije/Publications |
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