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https://open.uns.ac.rs/handle/123456789/7956
Title: | Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq | Authors: | Jelena Živković Joao Barreira Dejan Stojković Tatjana Ćebović Celestino Santos-Buelga Zoran Maksimović Isabel Ferreira |
Keywords: | Veronica urticifolia;Phenolic profile;HPLC-DAD/ESI-MS;Antibacterial;Antimutagenicity;Ehrlich carcinoma | Issue Date: | 1-Jan-2014 | Journal: | Journal of Functional Foods | Abstract: | The phenolic profile and antibacterial, antimutagenic and antitumour activities of the methanolic extracts of Veronica urticifolia Jacq. were evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumour activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumour cell viability, while ascites volume and tumour cell count became slightly decreased, but not to a statistically significant extent. The results indicate that V. urticifolia deserves further research into its potential chemoprevention effects. © 2014 Elsevier Ltd. | URI: | https://open.uns.ac.rs/handle/123456789/7956 | ISSN: | 17564646 | DOI: | 10.1016/j.jff.2014.04.024 |
Appears in Collections: | MDF Publikacije/Publications |
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