Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/7956
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jelena Živković | en_US |
dc.contributor.author | Joao Barreira | en_US |
dc.contributor.author | Dejan Stojković | en_US |
dc.contributor.author | Tatjana Ćebović | en_US |
dc.contributor.author | Celestino Santos-Buelga | en_US |
dc.contributor.author | Zoran Maksimović | en_US |
dc.contributor.author | Isabel Ferreira | en_US |
dc.date.accessioned | 2019-09-30T09:05:37Z | - |
dc.date.available | 2019-09-30T09:05:37Z | - |
dc.date.issued | 2014-01-01 | - |
dc.identifier.issn | 17564646 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/7956 | - |
dc.description.abstract | The phenolic profile and antibacterial, antimutagenic and antitumour activities of the methanolic extracts of Veronica urticifolia Jacq. were evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumour activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumour cell viability, while ascites volume and tumour cell count became slightly decreased, but not to a statistically significant extent. The results indicate that V. urticifolia deserves further research into its potential chemoprevention effects. © 2014 Elsevier Ltd. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Functional Foods | en_US |
dc.subject | Veronica urticifolia | en_US |
dc.subject | Phenolic profile | en_US |
dc.subject | HPLC-DAD/ESI-MS | en_US |
dc.subject | Antibacterial | en_US |
dc.subject | Antimutagenicity | en_US |
dc.subject | Ehrlich carcinoma | en_US |
dc.title | Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.doi | 10.1016/j.jff.2014.04.024 | - |
dc.identifier.scopus | 2-s2.0-84902650601 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84902650601 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 201 | en_US |
dc.relation.firstpage | 192 | en_US |
dc.relation.issue | 1 | en_US |
dc.relation.volume | 9 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet, Katedra za biohemiju | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | MDF Publikacije/Publications |
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