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https://open.uns.ac.rs/handle/123456789/7867
Nаziv: | MMP-1 and -3 haplotype is associated with congenital anomalies of the kidney and urinary tract | Аutоri: | Djuric T. Živković, Milica Milosevic, Biljana Andjelevski M. Cvetkovic, Mirjana Kostić, Marko Stankovic A. |
Dаtum izdаvаnjа: | 1-јан-2014 | Čаsоpis: | Pediatric Nephrology | Sažetak: | Background: Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of progressive chronic kidney disease that may lead to end-stage renal disease and renal replacement therapy in childhood. Altered expression or activity of matrix metalloproteinases (MMPs) have been found in CAKUT. The MMP-1, -3, and -8 polymorphisms studied here are located in the gene promoters and alter expression. Our aim was to investigate associations of MMP polymorphisms, solely and in haplotypes, with CAKUT in children. Methods: A case-control study with 101 pediatric patients and 281 controls was performed. The MMP-1 (-1607 1G/2G), -3 (5A/6A), and -8 (-799 C/T) genotypes were determined by PCR-restriction fragment length polymorphism. Results: We found statistically significant associations of MMP-3 5A/6A polymorphism (p<0.0001) and 1G-1607-6A haplotype, with no preferences for MMP-8 -799C or T alleles, with CAKUT (OR=2.93, 95 % CI 1.43-5.98, adjusted for gender, p=0.003) and with obstructive uropathies in a subgroup of patients (OR=4.57, 95 % CI 2.74-7.61, adjusted for gender, p<0.0001). Conclusions: MMP-3 genotypes and MMP-3 and -1 haplotypes encompassing either MMP-8 -799C or T alleles were associated with CAKUT and obstructive uropathies in pediatric patients. Still, functional and association studies are needed to elucidate evident roles of MMPs in CAKUT. © 2014 IPNA. | URI: | https://open.uns.ac.rs/handle/123456789/7867 | ISSN: | 0931041X | DOI: | 10.1007/s00467-013-2699-x |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
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