Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/767
DC Field | Value | Language |
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dc.contributor.author | Špirić Z. | en |
dc.contributor.author | Vještica, Marko | en |
dc.contributor.author | Erić, Mirjana | en |
dc.date.accessioned | 2019-09-23T10:10:58Z | - |
dc.date.available | 2019-09-23T10:10:58Z | - |
dc.date.issued | 2019-01-01 | en |
dc.identifier.issn | 17843286 | en |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/767 | - |
dc.description.abstract | © 2019, © 2019 Acta Clinica Belgica. Objectives: Melanoma induces lymphangiogenesis by secreting lymphangiogenic growth factors. The aim of this study was to examine the role of tumour lymphangiogenesis in survival of patients with cutaneous melanoma. Methods: Immunostaining of one hundred melanoma specimens was done with lymphatic-specific antibody D2-40. The quantification of tumour lymphangiogenesis–lymphatic vessel density (LVD) and lymphatic vessel area (LVA)–was calculated by computer-assisted morphometric analysis. Results: High intratumoural LVD, high peritumoural LVD, male gender, greater tumour thickness and Clark level IV/V were significantly associated with shorter disease-free survival (p = 0.001, p = 0.004, p = 0.004, p = 0.000 and p = 0.008, respectively) and melanoma-specific survival (p = 0.002, p = 0.002, p = 0.001, p = 0.000 and p = 0.017, respectively), while the trunk melanoma site was significantly associated only with shorter disease-free survival (p = 0.033). No significant association of LVA with survival was found. At multivariate analysis, peritumoural LVD [hazard ratio (HR) = 2.143, 95% confidence interval (CI) 1.097–4.189, p = 0.026)] and melanoma thickness (HR = 1.276, 95%CI 1.106–1.473, p = 0.001) were independent predictors of disease-free survival, while intratumoural LVD (HR = 3.446, 95%CI 1.465–8.109, p = 0.005), peritumoural LVD (HR = 2.742, 95%CI 1.313–5.725, p = 0.007) and gender (HR = 2.880, 95%CI 1.304–6.362, p = 0.009) were independent predictors of melanoma-specific survival. Conclusion: Тhis study shows that LVD enables better prediction of survival than melanoma thickness and other clinical-pathological parameters. Intratumoural LVD is the most significant predictor of melanoma-specific survival, while only peritumoural LVD has a significant impact on both, a disease-free survival and a melanoma-specific survival. | en |
dc.relation.ispartof | Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine | en |
dc.title | Survival prediction in patients with cutaneous melanoma by tumour lymphangiogenesis | en |
dc.type | Journal/Magazine Article | en |
dc.identifier.doi | 10.1080/17843286.2019.1629076 | en |
dc.identifier.scopus | 2-s2.0-85067809733 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85067809733 | en |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Fakultet tehničkih nauka, Departman za računarstvo i automatiku | - |
crisitem.author.parentorg | Fakultet tehničkih nauka | - |
Appears in Collections: | FTN Publikacije/Publications |
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