Chemometric study of retention indices of some thiazolidinediones derivatives in two low polarity stationary phases

Abstract

Application of chemometric methods in the study of the retention indices of thirteen 5-Arylidene-2,4- thiazolidinediones in two low polarity high-Performance thin-Layer chromatographic (HPTLC) stationary phases (RP-18 and RP-CN) and six aqueous mobile phases. Principal component analysis classified chromatographic systems into four specific groups while one system remained non-Classified. Hierarchical clustering analysis enabled grouping of the chromatographic systems into three clusters, and the studied compounds into three main classes. The color map enabled more in-Depth interpretation of the relationships between the studied compounds and HPTLC systems applied. © 2014 Bentham Science Publishers.