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https://open.uns.ac.rs/handle/123456789/7654
Назив: | Pharmacokinetics and toxicity predictors of new s-triazines, herbicide candidates, in correlation with chromatogrpahic retention constants | Аутори: | Milošević, Nataša Janjić, Nataša Milić, Nataša Milanović, Maja Popović, Jovan Antonović, Dušan |
Датум издавања: | 1-јан-2014 | Часопис: | Journal of Agricultural and Food Chemistry | Сажетак: | Herbicides, which are ubiquitously present in soil and food, have been proven to cause human health hazard effects, hence development of new herbicide-active compounds is recommended. In this paper, nine 2,4-bis(cycloalkyl)-6-chloro-s-triazines were considered as herbicide candidates and their pharmacokinetics and toxicity were reviewed on the basis of in silico descriptors. Both, pharmacokinetic and toxicity predictors were presented as functions of their lipophilicity, quantified with retention constants that were obtained by liquid chromatography. None of the candidates investigated has functional groups for genotoxicity hazards and endocrine disruptions; they have acceptable toxicity and favorable pharmacokinetic properties based on computer-aided analyses. Two candidates have been selected as lead compounds for further research. © 2014 American Chemical Society. | URI: | https://open.uns.ac.rs/handle/123456789/7654 | ISSN: | 00218561 | DOI: | 10.1021/jf502405k |
Налази се у колекцијама: | MDF Publikacije/Publications |
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