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https://open.uns.ac.rs/handle/123456789/7366
Title: | Multivitamin mineral supplementation in patients with chronic fatigue syndrome | Authors: | Daniela Marić Snežana Brkić Aleksandra Novakov Mikić Slavica Tomić Tatjana Ćebović Vesna Turkulov |
Keywords: | chronic fatigue syndrome;oxidative stress;quality of life;vitamins | Issue Date: | 14-Jan-2014 | Journal: | Medical Science Monitor | Abstract: | Background: Chronic fatigue syndrome (CFS) is characterized by medically unexplained persistent or reoccurring fatigue lasting at least 6 months. CFS has a multifactorial pathogenesis in which oxidative stress (OS) plays a prominent role. Treatment is with a vitamin and mineral supplement, but this therapeutic option so far has not been properly researched. Material and Methods: This prospective study included 38 women of reproductive age consecutively diagnosed by CDC definition of CFS and treated with a multivitamin mineral supplement. Before and after the 2-month supplementation, SOD activity was determined and patients self-assessed their improvement in 2 questionnaires: the Fibro Fatigue Scale (FFS) and the Quality of Life Scale (SF36). Results: There was a significant improvement in SOD activity levels; and significant decreases in fatigue (p=0.0009), sleep disorders (p=0.008), autonomic nervous system symptoms (p=0.018), frequency and intensity of headaches (p=0.0001), and subjective feeling of infection (p=0.0002). No positive effect on quality of life was found. Conclusions: Treatment with a vitamin and mineral supplement could be a safe and easy way to improve symptoms and quality of life in patients with CFS. © Med Sci Monit. | URI: | https://open.uns.ac.rs/handle/123456789/7366 | ISSN: | 12341010 | DOI: | 10.12659/MSM.889333 |
Appears in Collections: | MDF Publikacije/Publications |
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