Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе:
https://open.uns.ac.rs/handle/123456789/7292
Nаziv: | Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4′-leucine-avarone | Аutоri: | Pejin B. Iodice C. Tommonaro G. Bogdanovic G. Kojić, Vesna De Rosa S. |
Dаtum izdаvаnjа: | 4-мар-2014 | Čаsоpis: | Natural Product Research | Sažetak: | The cytotoxicity of 4′-leucine-avarone, amino derivative of the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay in vitro against seven human solid tumours for the first time. The compound tested induced dose-dependent cytotoxic response in all cancer cells showing better activity towards the lung A-549 and colon HT-29 cell lines (IC50 7.40 μM and 9.62 μM, respectively) than towards the breast adenocarcinoma ER positive MCF-7 and ER negative MDA-MB-231 cells (IC50 11.64 μM and 17.31 μM, respectively), the prostate adenocarcinoma PC-3 and epiteloid cervix carcinoma HeLa cells (IC50 14.24 μM and 15.54 μM, respectively). No toxicity was found towards the foetal lung fibroblast MRC-5 cell line at the concentrations used. According to experimental data obtained, the sesquiterpenoid quinone structure of avarone may inspire development of new drug-like substances with improved cytotoxicity on lung cancer in humans. © 2014 © 2014 Taylor & Francis. | URI: | https://open.uns.ac.rs/handle/123456789/7292 | ISSN: | 14786419 | DOI: | 10.1080/14786419.2013.863201 |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
Prikаzаti cеlоkupаn zаpis stаvki
SCOPUSTM
Nаvоđеnjа
40
prоvеrеnо 10.05.2024.
Prеglеd/i stаnicа
22
Prоtеklа nеdеljа
8
8
Prоtеkli mеsеc
0
0
prоvеrеnо 10.05.2024.
Google ScholarTM
Prоvеritе
Аlt mеtrikа
Stаvkе nа DSpace-u su zаštićеnе аutоrskim prаvimа, sа svim prаvimа zаdržаnim, оsim аkо nije drugačije naznačeno.