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https://open.uns.ac.rs/handle/123456789/7292
Title: | Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4′-leucine-avarone | Authors: | Pejin B. Iodice C. Tommonaro G. Bogdanovic G. Kojić, Vesna De Rosa S. |
Issue Date: | 4-Mar-2014 | Journal: | Natural Product Research | Abstract: | The cytotoxicity of 4′-leucine-avarone, amino derivative of the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay in vitro against seven human solid tumours for the first time. The compound tested induced dose-dependent cytotoxic response in all cancer cells showing better activity towards the lung A-549 and colon HT-29 cell lines (IC50 7.40 μM and 9.62 μM, respectively) than towards the breast adenocarcinoma ER positive MCF-7 and ER negative MDA-MB-231 cells (IC50 11.64 μM and 17.31 μM, respectively), the prostate adenocarcinoma PC-3 and epiteloid cervix carcinoma HeLa cells (IC50 14.24 μM and 15.54 μM, respectively). No toxicity was found towards the foetal lung fibroblast MRC-5 cell line at the concentrations used. According to experimental data obtained, the sesquiterpenoid quinone structure of avarone may inspire development of new drug-like substances with improved cytotoxicity on lung cancer in humans. © 2014 © 2014 Taylor & Francis. | URI: | https://open.uns.ac.rs/handle/123456789/7292 | ISSN: | 14786419 | DOI: | 10.1080/14786419.2013.863201 |
Appears in Collections: | MDF Publikacije/Publications |
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