Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/6989
Title: | Probucol Release from Novel Multicompartmental Microcapsules for the Oral Targeted Delivery in Type 2 Diabetes | Authors: | Mooranian A. Negrulj R. Al-Sallami H. Fang Z. Momir Mikov Svetlana Goločorbin-Kon Fakhoury M. Watts G. Matthews V. Arfuso F. Lambros A. Al-Salami H. |
Keywords: | Probucol;Multicompartmental Microcapsules;Oral Targeted Delivery;Diabetes mellitus type 2 | Issue Date: | 1-Jan-2014 | Journal: | AAPS PharmSciTech | Abstract: | © 2014, American Association of Pharmaceutical Scientists. In previous studies, we developed and characterised multicompartmental microcapsules as a platform for the targeted oral delivery of lipophilic drugs in type 2 diabetes (T2D). We also designed a new microencapsulated formulation of probucol-sodium alginate (PB-SA), with good structural properties and excipient compatibility. The aim of this study was to examine the stability and pH-dependent targeted release of the microcapsules at various pH values and different temperatures. Microencapsulation was carried out using a Büchi-based microencapsulating system developed in our laboratory. Using SA polymer, two formulations were prepared: empty SA microcapsules (SA, control) and loaded SA microcapsules (PB-SA, test), at a constant ratio (1:30), respectively. Microcapsules were examined for drug content, zeta potential, size, morphology and swelling characteristics and PB release characteristics at pH 1.5, 3, 6 and 7.8. The production yield and microencapsulation efficiency were also determined. PB-SA microcapsules had 2.6 ± 0.25% PB content, and zeta potential of −66 ± 1.6%, suggesting good stability. They showed spherical and uniform morphology and significantly higher swelling at pH 7.8 at both 25 and 37°C (p < 0.05). The microcapsules showed multiphasic release properties at pH 7.8. The production yield and microencapsulation efficiency were high (85 ± 5 and 92 ± 2%, respectively). The PB-SA microcapsules exhibited distal gastrointestinal tract targeted delivery with a multiphasic release pattern and with good stability and uniformity. However, the release of PB from the microcapsules was not controlled, suggesting uneven distribution of the drug within the microcapsules. | URI: | https://open.uns.ac.rs/handle/123456789/6989 | DOI: | 10.1208/s12249-014-0205-9 |
Appears in Collections: | MDF Publikacije/Publications |
Show full item record
SCOPUSTM
Citations
48
checked on May 10, 2024
Page view(s)
17
Last Week
1
1
Last month
0
0
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.