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https://open.uns.ac.rs/handle/123456789/6987
Назив: | Growth in children with chronic kidney disease: 13 years follow up study | Аутори: | Salević P. Radović P. Milić, Nataša Bogdanović R. Paripović D. Paripović A. Golubović E. Milošević, Bojana Mulić B. Peco-Antić A. |
Датум издавања: | 1-јан-2014 | Часопис: | Journal of Nephrology | Сажетак: | © 2014, Italian Society of Nephrology. Background: Growth retardation is one of the most visible comorbid conditions of chronic kidney disease (CKD) in children. To our knowledge, published data on longitudinal follow-up of growth in pediatric patients with CKD is lacking from the region of South-East Europe. Herein we report the results from the Serbian Pediatric Registry of Chronic Kidney Disease.Methods: The data reported in the present prospective analysis were collected between 2000 and 2012. A total of 324 children with CKD were enrolled in the registry.Results: Prevalence of growth failure at registry entry was 29.3 %. Mean height standard deviation scores (HtSDS) in children with stunting and those with normal stature were −3.00 [95 % confidence interval (CI) −3.21 to −2.79] and −0.08 (95 % CI −0.22 to 0.05) (p < 0.001), respectively. Children with hereditary nephropathy had worse growth at registration (−1.51; 95 % CI −1.97 to −1.04, p = 0.008). Those with CKD stages 4 and 5 before registration had more chance to have short stature at registration than those with CKD stages 2 and 3 [odds ratio (OR) = 0.458, CI 0.268–0.782, p = 0.004]. Dialysis was an independent negative predictor for maintaining optimal stature during the follow-up period (OR = 0.324, CI = 0.199–0.529, p < 0.001), while transplantation was an independent positive predictor for improvement of small stature during follow-up (OR = 3.706, CI = 1.785–7.696, p < 0.001).Conclusion: Growth failure remains a significant problem in children with CKD, being worst in patients with hereditary renal disease. Growth is not improved by standard dialysis, but transplantation has a positive impact on growth in children. | URI: | https://open.uns.ac.rs/handle/123456789/6987 | ISSN: | 11218428 | DOI: | 10.1007/s40620-014-0094-8 |
Налази се у колекцијама: | MDF Publikacije/Publications |
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