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https://open.uns.ac.rs/handle/123456789/6601
Title: | Novel chenodeoxycholic acid-sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study | Authors: | Mooranian A. Negrulj R. Momir Mikov Svetlana Goločorbin-Kon Arfuso F. Al-Salami H. |
Keywords: | Bile acids;Diabetes mellitus type 2;chenodeoxycholic acid;microencapsulation;probucol | Issue Date: | 1-Jan-2015 | Journal: | Journal of Microencapsulation | Abstract: | © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted. Context: We previously designed, developed and characterized a novel microencapsulated formulation as a platform for the targeted delivery of Probucol (PB) in an animal model of Type 2 Diabetes. Objective: The objective of this study is to optimize this platform by incorporating Chenodeoxycholic acid (CDCA), a bile acid with good permeation-enhancing properties, and examine its effect in vitro. Using sodium alginate (SA), we prepared PB-SA (control) and PB-CDCA-SA (test) microcapsules. Results and discussion: CDCA resulted in better structural and surface characteristics, uniform morphology, and stable chemical and thermal profiles, while size and rheological parameters remained unchanged. PB-CDCA-SA microcapsules showed good excipients compatibilities, as evidenced by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy, scanning electron microscopy and energy dispersive X-ray spectroscopy studies. CDCA reduced microcapsule swelling at pH 7.8 at both 37 °C and 25 °C and improved PB-release. Conclusion: CDCA improved the characteristics and release properties of PB-microcapsules and may have potential in the targeted oral delivery of PB. | URI: | https://open.uns.ac.rs/handle/123456789/6601 | ISSN: | 2652048 | DOI: | 10.3109/02652048.2015.1065922 |
Appears in Collections: | MDF Publikacije/Publications |
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