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Title: | Estimation of chromatographic lipophilicity of some D-homo androstene derivatives | Authors: | Perišić Janjić, Nada Penov Gaši, Katarina Đurendić, Evgenija Savić (Zaviš), Marina Kovačević, Strahinja Jokić, Stela Podunavac-Kuzmanović, Sanja |
Issue Date: | 2015 | Publisher: | Novi Sad: University of Novi Sad, Faculty of Technology, Novi Sad | Journal: | Acta Periodica Technologica | Abstract: | Quantitative structure-retention relationship (QSRR) method was applied to study the chromatographic behaviour of D-homo-androstene derivatives 1-7. Retention constants (RM 0) of the analysed derivatives were determined by reversed-phase high-performancethin-layer chromatography (RP HPTLC) on C18 plates by using four mobile phase mixtures: methanol-water, acetone-water, acetonitrile-water, and dioxane-water. Correlationanalysis based on multiple regression method was applied in order to model chromatographic retention by means of nine different lipophilicity descriptors (logP). The developedQSRR models were cross-validated and high-quality validation parameters were obtained by leave-one-out method. It was found that the derived QSRR models have agood predictive ability. | URI: | https://open.uns.ac.rs/handle/123456789/6381 | ISSN: | 14507188 | DOI: | 10.2298/APT1546249P |
Appears in Collections: | TF Publikacije/Publications |
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