Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе: https://open.uns.ac.rs/handle/123456789/6145
Nаziv: The perinatal origins of major reproductive disorders in the adolescent: Research avenues
Аutоri: Brosens I.
Aleksandar Ćurčić 
Tihomir Vejnovic 
Gargett C.
Brosens J.
Benagiano G.
Ključnе rеči: Endometrium;Neonatal uterine bleeding;Progesterone resistance;Endometriosis;Obstetrical disorders
Dаtum izdаvаnjа: 1-апр-2015
Čаsоpis: Placenta
Sažetak: © 2015 Elsevier Ltd. All rights reserved. The fetal endometrium becomes responsive to steroid hormones around the fourth month of pregnancy starting with an oestrogenic phase, which is followed late in pregnancy by a secretory phase. Based on post-mortem studies, the endometrium at birth is secretory in only one-third of neonates and proliferative in the remaining cases. Decidual or menstrual changes are rare in fetal endometrium despite high circulating steroid hormone levels, which drop rapidly after birth. Hence, acquisition of progesterone responsiveness appears to be dependent on endometrial maturation and relative immaturity may persist in a majority of girls until the menarche and early adolescence. Two major reproductive disorders have been linked with either advanced or delayed endometrial maturation. First, early-onset endometriosis may be caused by menstruation-like bleeding in the neonate, leading to tubal reflux and ectopic implantation of endometrial stem/progenitor cells. Second, persistence of partial progesterone resistance in adolescent girls may compromise deep placentation and account for the increased risk of major obstetrical syndromes, including preeclampsia, fetal growth retardation and preterm birth. The concept of neonatal origins of common reproductive disorders poses important research challenges but also subsumes potential new preventative strategies.
URI: https://open.uns.ac.rs/handle/123456789/6145
ISSN: 1434004
DOI: 10.1016/j.placenta.2015.01.003
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