Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе:
https://open.uns.ac.rs/handle/123456789/5901
Nаziv: | In vitro evaluation of cytotoxic and mutagenic activity of avarol | Аutоri: | Pejin B. Iodice C. Kojić, Vesna Jakimov D. Lazovic M. Tommonaro G. |
Dаtum izdаvаnjа: | 1-јан-2016 | Čаsоpis: | Natural Product Research | Sažetak: | © 2015 Taylor & Francis. The cytotoxicity of avarol, a main secondary metabolite of the Mediterranean sponge Dysidea avara, was in vitro screened by MTT assay against four human tumour cell lines. The colon HT-29 tumour cells practically showed to be the only sensitive ones towards this organic compound. No toxicity was found against the fetal lung fibroblast MRC-5 cells at the concentrations tested. In comparison with doxorubicin, used as a positive control, avarol actually exhibited at least 588-fold less toxicity towards normal MRC-5 cells. Finally, comet assay indicated that DNA fragmentation was almost fivefold higher upon the treatment with doxorubicin, compared to avarol. The obtained results have actually confirmed that avarol scaffold may contribute to development of new cytostatics inspired by nature. | URI: | https://open.uns.ac.rs/handle/123456789/5901 | ISSN: | 14786419 | DOI: | 10.1080/14786419.2015.1052067 |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
Prikаzаti cеlоkupаn zаpis stаvki
SCOPUSTM
Nаvоđеnjа
11
prоvеrеnо 10.05.2024.
Prеglеd/i stаnicа
22
Prоtеklа nеdеljа
8
8
Prоtеkli mеsеc
0
0
prоvеrеnо 10.05.2024.
Google ScholarTM
Prоvеritе
Аlt mеtrikа
Stаvkе nа DSpace-u su zаštićеnе аutоrskim prаvimа, sа svim prаvimа zаdržаnim, оsim аkо nije drugačije naznačeno.