Influence of ketoprofen application on lipid mobilization, ketogenesis and metabolic status in cows during early lactation

Abstract

© 2016 Veteriner Fakultesi Dergisi. All rights reserved. Changes in metabolic functions in transition dairy cows represent a result of negative energy balance. This leads to increased lipid mobilization and ketogenesis, followed by increased concentrations of non-esterified fatty acids (NEFA) and beta-hydroxybutyrate (BHB). Hence, high lipid mobilization and ketogenesis modulate inflammation response and vice versa. The aim of this study was to investigate correlations between ketoprofen administration, high lipid mobilization, ketogenesis and characteristics of metabolic adaptation in cows. Ketoprofen was administered intramuscularly in the concentration of 3 mg/kg, during three consecutive days in 15 postpartum cows. The control group included 15 cows which were not treated with ketoprofen. Blood samples were taken from coccygeal vein, after calving, in the first and second week of the postpartum period. When compared with control, ketoprofen administration decrease the levels of NEFA, BHB and total bilirubin, increase levels of glucose, albumin and cholesterol. Our results showed decreased activity of AST in ketoprofen treated cows in comparison with control group. There was an increase in the intensity of lipolysis and ketogenesis in 66.7% of cows, with NEFA and BHB values over the optimal results, because ketoprofen was not applied to these animals. Cows in the control group were 2 or 2.4 times more likely to come to a state of increased lipid mobilization and ketogenesis. We have found high concordance between NEFA and BHB, and metabolic parameters. This correlation was lower in experimental group of cows hence we can conclude that the use of ketoprofen immediately after calving reduces lipid mobilization and ketogenesis during early lactation and the metabolic adaptation dependence on the intensity of these two processes.