Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/5112
Title: | Comparison of the efficiency of clomiphene citrate and letrozole in combination with metformin in moderately obese clomiphene citrate – Resistant polycystic ovarian syndrome patients | Authors: | Artur Bjelica Aleksandra Trninić Pjević Ljiljana Mladenović Segedi Nenad Ćetković Đorđe Petrović |
Keywords: | clomiphene citrate;letrozole;polycystic ovarian syndrome | Issue Date: | 1-Jan-2016 | Journal: | Srpski Arhiv za Celokupno Lekarstvo | Abstract: | © 2016, Serbia Medical Society. All rights reserved. Introduction Polycystic ovary syndrome is the most common endocrinopathy in women of reproductiveage. Therapy for those who want to get pregnant involves ovulation induction using clomiphene citrate, metformin, letrozole and gonadotropins. Objective The aim of the study was to compare the efficacy of combinations of clomiphene citrate–metformin and letrozole–metformin in obese patients who are resistant to clomiphene citrate alone. Methods The investigation was conducted as a retrospective study involving 60 moderately obese patients with polycystic ovary syndrome. Thirty-one of them received the clomiphene citrate–metformin, and 29 letrozole–metformin therapy. Stimulation was carried out for the procedures of intrauterine insemination (IUI). Results The age of patients, duration of infertility, and body mass index in both groups were similar. There was statistically significant difference in the thickness of the endometrium in favor of the group having the letrozole–metformin therapy (8.9±1.7 mm) compared with the group receiving the clomiphene citrate–metformin treatment (6.3±1.3 mm). The number of follicles was not statistically significantly different. Pregnancy rate in the first cycle of IUI in the clomiphene citrate group was 6.4%, and 17.2% in the letrozole group, which also was not statistically different. After the third IUI cycle, the pregnancy rate was significantly higher in the letrozole group (20.6%), while in the clomiphene citrate group it was (9.6%). Conclusion This retrospective study demonstrated the advantages of the use of letrozole over clomiphene citrate in combination with metformin in moderately obese patients with polycystic ovary syndrome who are resistant to stimulation with clomiphene citrate alone. | URI: | https://open.uns.ac.rs/handle/123456789/5112 | ISSN: | 3708179 | DOI: | 10.2298/SARH1604146B |
Appears in Collections: | MDF Publikacije/Publications |
Show full item record
SCOPUSTM
Citations
6
checked on May 10, 2024
Page view(s)
31
Last Week
2
2
Last month
0
0
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.