Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/3967
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Maja Đanić | en_US |
dc.contributor.author | Nebojša Pavlović | en_US |
dc.contributor.author | Bojan Stanimirov | en_US |
dc.contributor.author | Tijana Ostojić | en_US |
dc.contributor.author | Svetlana Goločorbin-Kon | en_US |
dc.contributor.author | Gordana Smieško | en_US |
dc.contributor.author | Momir Mikov | en_US |
dc.date.accessioned | 2019-09-23T10:31:12Z | - |
dc.date.available | 2019-09-23T10:31:12Z | - |
dc.date.issued | 2016-01-01 | - |
dc.identifier.issn | 11283602 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/3967 | - |
dc.description.abstract | OBJECTIVE: The aim of this study was to estimate the binding-affinities of different bile acids towards drug transporters in Lactobacillus acidophilus and Bifidobacterium longum in order to predict the influence of bile acids and probiotics interactions on drug pharmacokinetics. MATERIALS AND METHODS: In order to study interactions of bile acids with transporters of intestinal bacteria, molecular-docking step was performed, using SwissDock web-service. For the purpose of comparison, two natural bile acids, cholic acid (CA) and deoxycholic acid (DCA), and one semi-synthetic bile acid, 12-monoketocholic acid (MKC), were studied in parallel. The free-binding energy was used as the main criterion for ranking ligands. RESULTS: Studied bile acids exhibited different binding affinities towards bacterial transporters with MKC showing the most prominent effect. For the majority of studied transporters, the estimated affinities of bile acids decreased in the following order: MKC-CA-DCA. Namely, 38.7% of examined transport proteins gave the lowest free-binding energy with MKC. The weak inverse relationship between numbers of hydrogen bonds and estimated free-binding energies was revealed. CONCLUSIONS: The predominant effect of MKC for the majority of studied transport proteins suggests that keto group at carbon 12 of the steroid core has a significant influence on the properties of MKC and consequently, on interactions with membrane transporters. Present findings might have a role in the prediction of potential influence of bile acids and probiotics on drug pharmacokinetics. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | European Review for Medical and Pharmacological Sciences | en_US |
dc.subject | Docking study | en_US |
dc.subject | Probiotics | en_US |
dc.subject | Transport proteins | en_US |
dc.subject | Bile acids | en_US |
dc.subject | Drug transport | en_US |
dc.title | Docking-based preliminary study on the interactions of bile acids with drugs at the transporter level in intestinal bacteria | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.pmid | 20 | - |
dc.identifier.scopus | 2-s2.0-85017177123 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85017177123 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 560 | en_US |
dc.relation.firstpage | 553 | en_US |
dc.relation.issue | 3 | en_US |
dc.relation.volume | 20 | en_US |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmakologiju i toksikologiju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za farmaciju | - |
crisitem.author.dept | Medicinski fakultet, Katedra za biohemiju | - |
crisitem.author.dept | Fakultet tehničkih nauka, Departman za opšte discipline u tehnici | - |
crisitem.author.dept | Medicinski fakultet, Katedra za mikrobiologiju sa parazitologijom i imunologijom | - |
crisitem.author.orcid | 0000-0002-7785-0666 | - |
crisitem.author.orcid | 0000-0002-9444-5830 | - |
crisitem.author.orcid | 0000-0002-0708-3182 | - |
crisitem.author.orcid | https://orcid.org/0000-0002-9257-8074 | - |
crisitem.author.orcid | 0000-0002-8276-2636 | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Medicinski fakultet | - |
crisitem.author.parentorg | Fakultet tehničkih nauka | - |
crisitem.author.parentorg | Medicinski fakultet | - |
Appears in Collections: | FTN Publikacije/Publications |
SCOPUSTM
Citations
9
checked on May 6, 2023
Page view(s)
56
Last Week
7
7
Last month
7
7
checked on May 10, 2024
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.