Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/32746
DC Field | Value | Language |
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dc.contributor.author | Miler, Irena | en_US |
dc.contributor.author | Rabasović, Mihailo | en_US |
dc.contributor.author | Stylianou, Andreas | en_US |
dc.contributor.author | Korać, Bato | en_US |
dc.contributor.author | Korać, Aleksandra | en_US |
dc.date.accessioned | 2024-05-12T15:02:05Z | - |
dc.date.available | 2024-05-12T15:02:05Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 2306-5354 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/32746 | - |
dc.description.abstract | Changes in the structural properties of the skin due to collagen alterations are an important factor in diabetic skin complications. Using a combination of photonic methods as an optic diagnostic tool, we investigated the structural alteration in rat dermal collagen I in diabetes, and after short-term l-arginine treatment. The multiplex approach shows that in the early phase of diabetes, collagen fibers are partially damaged, resulting in the heterogeneity of fibers, e.g., “patchy patterns” of highly ordered/disordered fibers, while l-arginine treatment counteracts to some extent the conformational changes in collagen-induced by diabetes and mitigates the damage. Raman spectroscopy shows intense collagen conformational changes via amides I and II in diabetes, suggesting that diabetes-induced structural changes in collagen originate predominantly from individual collagen molecules rather than supramolecular structures. There is a clear increase in the amounts of newly synthesized proline and hydroxyproline after treatment with l-arginine, reflecting the changed collagen content. This suggests that it might be useful for treating and stopping collagen damage early on in diabetic skin. Our results demonstrate that l-arginine attenuates the early collagen I alteration caused by diabetes and that it could be used to treat and prevent collagen damage in diabetic skin at a very early stage. | en_US |
dc.relation.ispartof | Bioengineering | en_US |
dc.subject | dermal collagen I; diabetes; l-arginine; polarization-resolved SHG imaging; Raman spectromicroscopy; AFM | en_US |
dc.title | Short-Term l-arginine Treatment Mitigates Early Damage of Dermal Collagen Induced by Diabetes | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3390/bioengineering11040407 | - |
dc.identifier.scopus | 2-s2.0-85191529720 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 12 | en_US |
dc.relation.firstpage | 1 | en_US |
dc.relation.issue | 4 | en_US |
dc.relation.volume | 11 | en_US |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Institut BioSense | - |
crisitem.author.orcid | 0000-0001-9258-8320 | - |
crisitem.author.parentorg | Univerzitet u Novom Sadu | - |
Appears in Collections: | IBS Publikacije/Publications |
Files in This Item:
File | Size | Format | |
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bioengineering-11-00407-v2.pdf | 2.45 MB | Adobe PDF | View/Open |
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