Molecular epidemiology of colistin-resistant, carbapenemase-producing Klebsiella pneumoniae in Serbia from 2013 to 2016

Please use this identifier to cite or link to this item: https://open.uns.ac.rs/handle/123456789/3263

Title:	Molecular epidemiology of colistin-resistant, carbapenemase-producing Klebsiella pneumoniae in Serbia from 2013 to 2016
Authors:	Katarina Novović Anika Trudić Snežana Brkić Zorica Vasiljević Milan Kojić Deana Medić ivana Ćirković Branko Jovčić
Keywords:	Klebsiella pneumoniae;carbapenem resistance;colistin resistance;molecular epidemiology
Issue Date:	1-May-2017
Journal:	Antimicrobial Agents and Chemotherapy
Abstract:	Copyright © 2017 American Society for Microbiology. All Rights Reserved. Twenty-seven colistin-resistant, carbapenemase-producing Klebsiella pneumoniae isolates were identified from hospitals in Serbia. All isolates were blaCTX-M-15 positive; ST101, ST888, ST437, ST336, and ST307 were blaOXA-48 positive; and ST340 was blaNDM-1 positive. ST307 had an insertion, and ST336 had a premature stop codon in the mgrB gene. Amino acid substitutions were detected in PmrAB of isolates ST101, ST888, ST336, and ST307. The mcr-1 and mcr-2 were not detected. An increase in phoP, phoQ, and pmrK gene transcription was detected for all sequence types.
URI:	https://open.uns.ac.rs/handle/123456789/3263
ISSN:	664804
DOI:	10.1128/AAC.02550-16
Appears in Collections:	MDF Publikacije/Publications

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