Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/32459
DC Field | Value | Language |
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dc.contributor.author | Susbin Raj Wagle | en_US |
dc.contributor.author | Božica Kovačević | en_US |
dc.contributor.author | Daniel Walker | en_US |
dc.contributor.author | Corina Mihaela Ionescu | en_US |
dc.contributor.author | Melissa Jones | en_US |
dc.contributor.author | Goran Stojanović | en_US |
dc.contributor.author | Sanja Kojić | en_US |
dc.contributor.author | Armin Mooranian | en_US |
dc.contributor.author | Hani Al-Salami | en_US |
dc.date.accessioned | 2022-07-03T12:13:20Z | - |
dc.date.available | 2022-07-03T12:13:20Z | - |
dc.date.issued | 2020-07-29 | - |
dc.identifier.issn | 1999-4923 | en_US |
dc.identifier.uri | https://open.uns.ac.rs/handle/123456789/32459 | - |
dc.description.abstract | Bile acids have recently been studied for potential applications as formulation excipients and enhancers for drug release; however, some bile acids are not suitable for this application. Unconjugated lithocholic acid (ULCA) has recently shown drug formulation-stabilizing and anti-inflammatory effects. Lipophilic drugs have poor gut absorption after an oral dose, which necessitates the administration of high doses and causes subsequent side effects. Probucol (PB) is a highly lipophilic drug with poor oral absorption that resulted in restrictions on its clinical prescribing. Hence, this study aimed to design new delivery systems for PB using ULCA-based matrices and to test drugformulation, release, temperature, and biological effects. ULCA-based matrices were formulated for PB oral delivery by applying the jet-flow microencapsulation technique using sodium alginate as a polymer. ULCA addition to new PB matrices improved the microcapsule’s stability, drug release in vitro (formulation study), and showed a promising effect in ex vivo study (p < 0.05), suggesting that ULCA can optimize the oral delivery of PB and support its potential application in diabetes treatment. | en_US |
dc.description.sponsorship | European Commission | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation | H2020 SALSETH | en_US |
dc.relation.ispartof | Pharmaceutics | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | bile acids | en_US |
dc.subject | diabetes mellitus | en_US |
dc.subject | formulation sciences | en_US |
dc.subject | Inflammation | en_US |
dc.subject | probucol | en_US |
dc.subject | unconjugated lithocholic acid | en_US |
dc.title | Pharmacological and Advanced Cell Respiration E ects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3390/pharmaceutics12080708 | - |
dc.description.version | Published | en_US |
dc.relation.lastpage | 17 | en_US |
dc.relation.firstpage | 1 | en_US |
dc.relation.issue | 708 | en_US |
dc.relation.volume | 12 | en_US |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Fakultet tehničkih nauka, Departman za energetiku, elektroniku i telekomunikacije | - |
crisitem.author.dept | Fakultet tehničkih nauka, Departman za energetiku, elektroniku i telekomunikacije | - |
crisitem.author.orcid | 0000-0003-2098-189X | - |
crisitem.author.orcid | 0000-0002-4092-9733 | - |
crisitem.author.parentorg | Fakultet tehničkih nauka | - |
crisitem.author.parentorg | Fakultet tehničkih nauka | - |
Appears in Collections: | FTN Publikacije/Publications |
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File | Description | Size | Format | |
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pharmaceutics-12-00708.pdf | 1.64 MB | Adobe PDF | View/Open |
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