Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/32287
Title: | Binary and Tertiary Mixtures of Satureja hortensis and Origanum vulgare Essential Oils as Potent Antimicrobial Agents Against Helicobacter pylori | Authors: | Lesjak Marija Simin Nataša Orcic Dejan Francišković Marina Knežević Petar Beara Ivana Aleksic Verica Svirčev Emilija Buzas Kristina Mimica-Dukić Neda |
Issue Date: | 2016 | Journal: | Phytotherapy Research | Abstract: | Copyright © 2015 John Wiley & Sons, Ltd. Essential oils possess strong antimicrobial activity, even against multiresistant Helicobacter pylori. Available therapies against H. pylori infection have multiple disadvantages, indicating a great need for a development of new therapeutics. The purpose of this study was to develop a potent natural product based anti-H. pylori formulation. First, anti-H. pylori activity of nine essential oils was determined, after which the most active oils were mixed in various ratios for further testing. Satureja hortensis, Origanum vulgare subsp. vulgare and O. vulgare subsp. hirtum essential oils expressed the highest activity (MIC = 2 μL mL-1). Their binary and ternary mixtures exhibited notably higher antimicrobial activity (MIC ≤ 2 μL mL-1). The most active was the mixture of S. hortensis and O. vulgare subsp. hirtum oils in volume ratio 2:1, which expressed 4 times higher activity than individual oils (MIC = 0.5 μL mL-1). According to GC-MS, both oils in the mixture were characterized by high content of phenols (48-73%), with carvacrol as the main carrier of antimicrobial activity. Presented in vitro study pointed out binary mixture of S. hortensis and O. vulgare subsp. hirtum essential oils in volume ratio 2:1 as promising candidate for further in vivo studies targeting H. pylori infection. | URI: | https://open.uns.ac.rs/handle/123456789/32287 | ISSN: | 0951-418X 1099-1573 |
DOI: | 10.1002/ptr.5552 |
Appears in Collections: | PMF Publikacije/Publications |
Show full item record
SCOPUSTM
Citations
31
checked on May 10, 2024
Page view(s)
32
Last Week
3
3
Last month
2
2
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.