Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе:
https://open.uns.ac.rs/handle/123456789/31423
Nаziv: | Synthesis, crystal structure and local anti-inflammatory activity of the L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid | Аutоri: | Dobričić Vladimir Francuski B Jacevic Vesna Rodić Marko Vladimirov Sote Čudina Olivera Francuski Đorđe |
Ključnе rеči: | 17β-carboxamide steroids, X-ray diffraction, biological activity, ear edema test | Dаtum izdаvаnjа: | 2015 | Čаsоpis: | Journal of the Serbian Chemical Society | Sažetak: | L-phenylalanine methyl ester derivative of dexamethasone - derived cortienic acid (DF) was synthesized and its crystal structure was characterized by X-ray diffraction method. The crystal system is orthorhombic with space group P212121 and cell constants a = 8.2969 (3) Å, b = 18.9358 (8) Å, c = 20.0904 (6) Å, V = 3156.4 (2) Å3 and Z = 4. Ring A of the steroid nucleus and phenyl ring in the 17β-side chain are almost planar. Rings B and C have a slightly distorted chair conformation, whereas ring D has an envelope conformation. The packing of DF is characterized by a network of intermolecular hydrogen bonds involving the O4 atom from one side of the steroid nucleus and O1 and F1 atoms from the other side as hydrogen bond acceptors. Apart from the intermolecular hydrogen bonds in the crystal packing, there are also numerous intramolecular hydrogen bonds of the N-H...O, C-H...O and C-H...F type. Local anti-inflammatory activity of DF was evaluated by use of croton oil-induced ear edema test. This derivative achieved maximal inhibition of ear edema at significantly lower concentration in comparison with dexamethasone. [Projekat Ministarstva nauke Republike Srbije, br. 172041, 172014 i 172035] | URI: | https://open.uns.ac.rs/handle/123456789/31423 | ISSN: | 0352-5139 | DOI: | 10.2298/JSC150505067D |
Nаlаzi sе u kоlеkciјаmа: | PMF Publikacije/Publications |
Prikаzаti cеlоkupаn zаpis stаvki
SCOPUSTM
Nаvоđеnjа
5
prоvеrеnо 10.05.2024.
Prеglеd/i stаnicа
25
Prоtеklа nеdеljа
2
2
Prоtеkli mеsеc
0
0
prоvеrеnо 10.05.2024.
Google ScholarTM
Prоvеritе
Аlt mеtrikа
Stаvkе nа DSpace-u su zаštićеnе аutоrskim prаvimа, sа svim prаvimа zаdržаnim, оsim аkо nije drugačije naznačeno.