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Title: | Determination of 17α-hydroxylase-C17,20-lyase (P45017α) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds | Authors: | Szabo Nikoletta Ajduković (Daljev) Jovana Ignáth Imre Sakač Marija Đurendić Evgenija János Gardi Mahmoud Gabor Jovanović-Šanta Suzana Penov-Gaši Katarina Mihály Szécsi |
Issue Date: | 2015 | Journal: | Acta Biologica Hungarica | Abstract: | © 2015 Akadémiai Kiadó, Budapest. 17α-hydroxylase-C17,20-lyase (P45017α) is a key regulator enzyme of the steroid hormone biosynthesis in both the adrenals and the testes. Inhibition of this enzyme can block androgen synthesis in an early step, and may thereby be useful in the treatment of several androgen-dependent diseases. We developed radiosubstrate in vitro incubation methods for the determination of the distinct 17α-hydroxylase and C17,20- lyase activities of the enzyme using rat testicular homogenate as enzyme source. With this method we have studied the inhibiting activity of selected steroidal picolyl and picolinylidene compounds. Tests revealed a substantial inhibitory action of the 17-picolinyliden-androst-4-en-3-one compound. | URI: | https://open.uns.ac.rs/handle/123456789/30783 | ISSN: | 0236-5383 1588-256X |
DOI: | 10.1556/ABiol.66.2015.1.4 |
Appears in Collections: | PMF Publikacije/Publications |
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