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https://open.uns.ac.rs/handle/123456789/3013
Title: | Evolution of the plasma proteome of divers before and after a single SCUBA dive | Authors: | Lautridou J. Pichereau V. Artigaud S. Bernay B. Otto Barak Hoiland R. Lovering A. Eftedal I. Dujic Z. Guerrero F. |
Keywords: | Decompression sickness;Plasma;Proteome;Proteomics;SCUBA | Issue Date: | 1-Sep-2017 | Journal: | Proteomics - Clinical Applications | Abstract: | © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Purpose: Decompression sickness (DCS) is a poorly understood and complex systemic disease caused by inadequate desaturation following a reduction of ambient pressure. A previous proteomic study of ours showed that DCS occurrence but not diving was associated with changes in the plasma proteome in rats, including a dramatic decrease of abundance of the tetrameric form of Transthyretin (TTR). The present study aims to assess the impact on the human blood proteome of a dive inducing significant decompression stress but without inducing DCS symptoms. Experimental design: Twelve healthy male divers were subjected to a single dive at a depth of 18 m of sea water (msw) with a 47-min bottom time followed by a direct ascent to the surface at a rate of 9 msw/min. Venous blood was collected before the dive as well as 30 min and 2 h following the dive. The plasma proteomes from four individuals were then analyzed by using a two-dimensional electrophoresis-based proteomic strategy. Results: No protein spot showed a significantly changed abundance (fdr< 0.1) between the tested times. Conclusion: These results strengthen the hypothesis according to which significant changes of the plasma proteome measurable with two-dimensional electrophoresis may only occur along with DCS symptoms. | URI: | https://open.uns.ac.rs/handle/123456789/3013 | ISSN: | 1862-8346 | DOI: | 10.1002/prca.201700016 |
Appears in Collections: | MDF Publikacije/Publications |
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