Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/29470
Title: | Conformationally constrained goniofufurone mimics as inhibitors of tumour cells growth: Design, synthesis and SAR study | Authors: | Benedeković Goran Francuz Jovana Kovačević Ivana Popsavin Mirjana Srećo Zelenović Bojana Kojic Vesna Bogdanovic Gordana Popsavin Velimir |
Issue Date: | 2014 | Journal: | European Journal of Medicinal Chemistry | Abstract: | Synthesis of conformationally restricted (+)-goniofufurone (1) and 7-epi-(+)-goniofufurone (2) analogues, with embedded O-isopropylidene, O-methylidene or cyclic carbonate functions is disclosed starting from d-glucose. A number of potential bioisosteres of 1 and 2 bearing both 5,7-O-methylidene and 4-substituted cinnamoyloxy functions at the C-7 position have also been synthesized. In vitro cytotoxicity of target molecules against a number of human tumour cell lines were recorded and compared with those observed for the parent molecules 1 and 2. Some of the analogues displayed powerful antiproliferative effects on selected human tumour cell lines, but all of them were devoid of any cytotoxicity towards the normal foetal lung fibroblasts (MRC-5). A SAR study reveals the structural features of these lactones that may increase their antiproliferative activity. © 2014 Elsevier Masson SAS. All rights reserved. | URI: | https://open.uns.ac.rs/handle/123456789/29470 | ISSN: | 0223-5234 | DOI: | 10.1016/j.ejmech.2014.05.081 |
Appears in Collections: | MDF Publikacije/Publications |
Show full item record
SCOPUSTM
Citations
19
checked on May 10, 2024
Page view(s)
44
Last Week
8
8
Last month
8
8
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.