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https://open.uns.ac.rs/handle/123456789/29095
Title: | Substituent effects on chromatographic retention data of 5-Arylidene-2,4-Thiazolidinediones in Qsar methodology | Authors: | Đaković-Sekulić Tatjana Lozanov-Crvenković Zagorka Rančić Milica Trišović Nemanja Ušćumlić Gordana |
Issue Date: | 2014 | Journal: | Journal of Liquid Chromatography and Related Technologies | Abstract: | Quantitative structure-retention relationship (QSRR) study of retention data of thirteen 5-arylidene-2,4-thiazolidinediones obtained by reversed phase HPTLC. The effect of substituents attached to aryliden ring on the properties of TZD molecule, whose retention is closely correlated to the inhibitory activity, was investigated. PCA was used to show similarities/dissimilarities among the compounds. Stepwise regression models were calculated for each mobile phase modifier used. The obtained models were characterized by good fit and predictive abilities. The descriptors included in the models are connected with both lipophilic and donor/acceptor interactions. © 2014 Taylor and Francis Group, LLC. | URI: | https://open.uns.ac.rs/handle/123456789/29095 | ISSN: | 1082-6076 1520-572X |
DOI: | 10.1080/10826076.2013.825858 |
Appears in Collections: | PMF Publikacije/Publications |
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