The study of retention and solvatochromic properties of the newly synthesized phenylacetamide derivatives

Abstract

<p>U ovoj doktorskoj disertaciji određene su retencione osobine i solvatohromni&nbsp;parametri tri serije novosintetizovanih derivata N&ndash;(supstituisanih fenil)&ndash;2&ndash;supstituisanih acetamida u različitim hromatografskim i solvatohromnim sistemima.&nbsp;Metode linearne regresije kao i metode multivariacione analize: Klaster analize (CA) i&nbsp;Analize glavnih komponenti (PCA) su primenjene s ciljem pronalaženja kvalitativne&nbsp;odnosno kvantitativne zavisnosti između eksperimentalno određenih retencionih kao i&nbsp;apsorpcionih parametara N&ndash;(supstituisanih fenil)&ndash;2-supstituisanih acetamida i&nbsp;primenjenih rastvarača, odnosno hemijskih osobina funkcionalane grupe prisutne u&nbsp;molekulu.</p>

<p>In this dissertation retention properties and solvatochromic parameters of<br />three series of the newly synthesized derivatives of N-(phenyl substituted)&ndash;2&ndash;<br />substituted acetamide were determined in various chromatographic and<br />solvatochromic systems. The method of linear regression and multivariate methods of<br />analysis: Cluster analysis (CA) and Principal component analysis (PCA) were applied<br />with the aim of finding the qualitative or quantitative dependence between<br />experimentally determined retention and absorption parameters of N-( phenyl<br />substituted)&ndash;2&ndash;substituted acetamides and applied solvents or chemical properties of<br />the functional group present in the molecules.</p>