Please use this identifier to cite or link to this item:
https://open.uns.ac.rs/handle/123456789/28689
Title: | Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone | Authors: | Đorđević Milena Jeremić Dejan Rodić Marko Simić Vera Brčeski I.D. Leovac Vukadin |
Issue Date: | 2014 | Journal: | Polyhedron | Abstract: | The reaction of an ethanolic solution of the newly synthesized 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone (HL) with aqueous solutions of K2[MCl4] (M = Pd(II), Pt(II)) resulted in neutral complexes of the general formulae [M(L)Cl]. These complexes have a square-planar structure that was achieved by tridentate PNO coordination of the monoprotonated Schiff base and a chloride ligand. The ligand and its metal complexes were analyzed for their antimicrobial activity and their in vitro cytotoxicity in human larynx carcinoma cells (Hep-2) and non-cancerous human lung fibroblast cells (MRC-5). The platinum(II) complex shows cytotoxicity towards Hep-2 cells comparable to oxaliplatin and exhibited improved selectivity for cancer cells. The ligand and its complexes were characterized by elemental analysis, NMR and IR spectroscopy, and single crystal X-ray diffraction analysis. © 2013 Elsevier Ltd. All rights reserved. | URI: | https://open.uns.ac.rs/handle/123456789/28689 | ISSN: | 0277-5387 | DOI: | 10.1016/j.poly.2013.10.029 |
Appears in Collections: | PMF Publikacije/Publications |
Show full item record
SCOPUSTM
Citations
24
checked on Nov 20, 2023
Page view(s)
16
Last Week
1
1
Last month
0
0
checked on May 10, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.