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https://open.uns.ac.rs/handle/123456789/28369
Nаziv: | Design, synthesis and antiproliferative activity ofnatural cytotoxic lactones and analogues Dizajn, sinteza i antiproliferativna aktivnost prirodnih citotoksičnih laktona i analoga |
Аutоri: | Srećo Zelenović Bojana | Ključnе rеči: | Cytotoxic lactones, goniofufurone, muricatacin, cardiobutanolide, analogues synthesis, SAR, antiproliferative activity;Citotoksični laktoni, goniofufuron, murikatacin, kardiobutanolid, sinteza analoga, SAR, antiproliferativna aktivnost | Dаtum izdаvаnjа: | 28-феб-2013 | Izdаvаč: | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu University of Novi Sad, Faculty of Sciences at Novi Sad |
Sažetak: | <p>Ostvarene su višefazne sinteze prirodnih citotoksičnih laktona (+)-murikatacina (<strong>1</strong>),<br />(–)-murikatacina (ent-<strong>1</strong>) i (+)-goniofufurona (<strong>2</strong>), kao i njihovih novih analoga (<strong>3a</strong>, <strong>4</strong>,<br /><strong>5</strong>, <strong>6</strong>, <strong>7</strong>, <strong>8</strong>, <strong>9</strong>, ent-<strong>7 </strong>i ent-<strong>9</strong>), polazeći iz D-ksiloze ili iz D-glukoze. Ispitana je in vitro<br />citotoksična aktivnost sintetizovanih prirodnih proizvoda i analoga prema<br />odabranim humanim tumorskim ćelijskim linijama (K562, HL-60, Jurkat, Raji, HT-29, MDA-MB 231 i HeLa), kao i prema ćelijama fetalnih fibroblasta pluća (MRC-5).</p> <p>Multiphase synthesis of natural cytotoxic lactones (+)-muricatacin (<strong>1</strong>),<br />(–)-muricatacin (ent-<strong>1</strong>) and (+)-goniofufurone (<strong>2</strong>), as well as synthesis of their<br />analogues (<strong>3a</strong>, <strong>4</strong>, <strong>5</strong>, <strong>6</strong>, <strong>7</strong>, <strong>8</strong>, <strong>9</strong>, ent-<strong>7</strong>and ent-<strong>9</strong>) was achived from D-xylose or<br />D-glucose as starting compounds. In vitro cytotoxic activity of synthetized natural<br />products and analogues against selected human tumour cell lines (K562, HL-60,<br />Jurkat, Raji, HT-29, MDA-MB 231 and HeLa) and against cells of natural foetal lung fibroblasts (MRC-5) was examined.</p> |
URI: | https://open.uns.ac.rs/handle/123456789/28369 |
Nаlаzi sе u kоlеkciјаmа: | PMF Teze/Theses |
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prоvеrеnо 10.05.2024.
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