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Title: | Synthesis and detailed biological testing of thiazole C-nucleozides Sinteza i detaljna biološka ispitivanja tiazolnih C-nukleozida |
Authors: | Kojić Vesna | Keywords: | Tiazofurin, D-arabinose, multistep synthesis, an acyclic analog tiazofurin, biological evaluation;Tiazofurin, D-arabinoza, višefazna sinteza, aciklični analog tiazofurina, biološka ispitivanja | Issue Date: | 26-Apr-2013 | Publisher: | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu University of Novi Sad, Faculty of Sciences at Novi Sad |
Abstract: | <p>U radu je ostvarena totalna sinteza novih acikličnih tiazolnih C-nukleozide sa dvostrukom vezom i 2′,3′-dideoksi funkcijom u šećernoj komponenti. Ostvarena višefazna sinteza pomenutih acikličnih analoga tiazofurina zasnovana je na D-arabinozi kao hiralnom prekursoru. Ispitana je in vitro citotoksična aktivnost novosintetizovanih nukleozida prema ćelijskim linijama K562, HL-60, HT-29, MCF-7, MDA-MB-231, HeLa, Raji, PC3, Jurkat, Hs 294T i MRC-5, kao i provera ćelijskih mehanizama koji su u osnovi uočenog citotoksičnog potencijala novosintetisanih analoga u odnosu na tiazofurin kao referentno jedinjenje.</p> <p>A total synthesis of new acyclic thiazole C-nucleozides bearing a double bond or 2′,3′-dideoxy functionality in the sugar moiety was achieved in this work. The multi-step synthesis of the mentioned thiazofurin analogues is based on D-arabinose as a chiral precursor. In vitro cytotoxic activity of newly synthesized compounds was evaluated against the following cell lines: K562, HL-60, HT-29, MCF-7, MDA-MB-231, HeLa, Raji, PC3, Jurkat, Hs 294T and MRC-5. A study of cell mechanisms underlaying the significant cytotoxic potential of these molecules was caried out and the results were compared to thiazofurin that servad as a referent compound in all biological testings.</p> |
URI: | https://open.uns.ac.rs/handle/123456789/28364 | DOI: | 10.2298/NS20130426KOJIC |
Appears in Collections: | PMF Teze/Theses |
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