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https://open.uns.ac.rs/handle/123456789/27699| Title: | Synthesis and Antiproliferative Activity of Thiazole C-Nucleosides and Their Mimics Sinteza i antiproliferativna aktivnost tiazolnih C-nukleozida i njihovih mimetika |
Authors: | Spaić Saša | Keywords: | C-Nucleosides, thiazoles, tiazofurin mimics, antiproliferative activity;C-Nukleozidi, tiazoli, mimetici tiazofurina, antiproliferativna aktivnost | Issue Date: | 8-Jul-2011 | Publisher: | Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu University of Novi Sad, Faculty of Sciences at Novi Sad |
Abstract: | <p>Ostvarene su višefazne stereospecifične sinteze tiazolnih C-nukleozida, novih analoga, odnosno mimetika tiazofurina polazeći iz D-glukoze i D-ksiloze. Ispitana je <em>in vitro </em>citotoksična aktivnost sintetizovanih C-nukleozida prema odabranim humanim tumorskim ćelijskim linijama (K562, HL 60, Jurkat, Raji, PC 3, HT-29, MCF-7, MDA-MB-231, HeLa i Hs 294T) kao i prema ćelijama normalnih fetalnih fibroblasta pluća (MRC-5).</p> <p>Multiphase stereospecific synthesis of thiazole C-nucleosides, new analogues and mimics of tiazofurin, has been achives starting from D-glucose and D-xylose. <br />We examined the in vitrocytotoxic activity of synthesized C-nucleosides by selected human tumor cell lines (K562, HL 60, Jurkat, Raji, PC 3, HT-29, MCF-7, <br />MDA-MB-231, HeLa and Hs 294T) and the cells of normal fetal lung fibroblasts (MRC-5).</p> |
URI: | https://open.uns.ac.rs/handle/123456789/27699 |
| Appears in Collections: | PMF Teze/Theses |
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