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Title: | The Synthesis of 2´, 3' - Dideoxynucleozides | Authors: | Ćetković, Gordana | Keywords: | Synthesis, 2´, 3'- dideoxynucleozides, D-xylose;Sinteza, 2´, 3'- dideoksinukleozidi, D-ksiloza | Issue Date: | 18-Dec-1998 | Publisher: | Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad University of Novi Sad, Faculty of Technology at Novi Sad |
Abstract: | U radu je ostvarena višefazna transformacija D-ksiloze u pogodno funkcionalizovane derivate koji su kuplovanjem sa siliranim timinom selektivno dali nukleozide sa beta-konfiguracijom na anomernom centru. Takođe, u cilju sinteze nukleozida L-serije, ispitana je mogućnost izomerizacije nekih derivata D-šečera u odgovarajuće L-stereoizomere. Muitistep transformation of D-xylose to suitabte functional derivatives were achieved. Coupling of these derivatives with silylated thymine gave the nucleosides with beta-configuration on anomeric centre. In order to synthesis nucleosides of L-series, the possibility for isomerization of some kinds D-sugar derivatives in corresponding L-stereisomeric compounds, were investigatet, too. |
URI: | https://open.uns.ac.rs/handle/123456789/27236 |
Appears in Collections: | TF Teze/Theses |
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