Thermal decomposition of new chlorido(p-cymene) ruthenium(II) complexes containing N-alkylphenothiazines

Abstract

The thermal decomposition of [RuCl2(g6-pcymene)] 2 (1) and its biologically active N-alkylphenothiazine compounds of composition L[RuCl3(g6-p-cymene)] where L = CPH? (2), TFH?HCl (3), and TRH? (4) (chlorpromazine hydrochloride, CPHCl; trifluoperazine dihydrochloride, TF2HCl; and thioridazine hydrochloride, TRHCl, respectively) has been studied. The crystal and molecular structure of compound 3 was determined earlier by single crystal X-ray diffraction analysis. The thermal data were collected by simultaneous TG/DSC measurements. For evolved gas detection, the qualitative reaction of chlorides with AgNO3 in an acidic solution was applied. The measurements were carried out in the temperature range to 700 C in nitrogen atmosphere. Compounds of L[RuCl3(g6-p-cymene)] crystallize with water or water/ 2-propanole. On the basis of thermal data, the trend in the solvent bonding energies was assessed.