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https://open.uns.ac.rs/handle/123456789/2608
Title: | Dietary guanidinoacetic acid does not accumulate in the brain of healthy men | Authors: | Ostojić, Sergej Ostojić, Jelena |
Keywords: | Glutamate;Guanidinoacetic acid;MR spectroscopy;Supplementation | Issue Date: | Dec-2018 | Journal: | European Journal of Nutrition | Abstract: | We conducted a secondary analysis of a previously completed trial to determine the effects of 8-week guanidinoacetic acid (GAA) loading on brain GAA levels in five healthy men. Brain magnetic resonance spectroscopy (1H-MRS) was taken at baseline and post-administration, with spectra additionally analyzed for brain GAA and glutamate concentrations using TARQUIN 4.3.10 software. Brain GAA levels remained essentially unchanged at follow-up (an increase of 7.7% from baseline levels; 95% confidence interval, - 24.1% to 39.5%; P = 0.88) when averaged across 12 white and grey matter voxel locations. No significant changes were found for brain glutamate levels during the study (P = 0.64). Supplemental GAA appears to be safe intervention concerning brain GAA deposition, at least with GAA dosages used. | URI: | https://open.uns.ac.rs/handle/123456789/2608 | ISSN: | 1436-6207 | DOI: | 10.1007/s00394-017-1600-2 |
Appears in Collections: | FSFV Publikacije/Publications MDF Publikacije/Publications |
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