Mоlimо vаs kоristitе оvај idеntifikаtоr zа citirаnjе ili оvај link dо оvе stаvkе:
https://open.uns.ac.rs/handle/123456789/2353
Nаziv: | Cross-linked guar gum and sodium borate based microspheres as colon-targeted anticancer drug delivery systems for 5-fluorouracil | Аutоri: | Kamal T. Sarfraz M. Arafat M. Momir Mikov Nisar-ur-Rahman |
Ključnе rеči: | 5-Fluorouracil;micro spheres;guar gum;colon drug delivery;anticancer delivery;sodium borate | Dаtum izdаvаnjа: | 1-нов-2017 | Čаsоpis: | Pakistan Journal of Pharmaceutical Sciences | Sažetak: | © 2018 Pakistan Journal of Pharmaceutical Sciences. All rights reserved. The aim was to prepare cross linked polymer of 5-fluorouracil loaded microspheres containing guar gum and sodium borate for colon-targeted drug delivery systems. Micro spheres were prepared using emulsification cross linking method. The influence of drug polymer ratio, cross linker agent concentrations and cross linking timing on in vitro drug release and characteristics in terms of drug loading, entrapment efficiency and yielding percentage were investigated. The optimum drug loading, entrapment efficiency and percent yield were obtained from formulations with the lowest content of cross linker agent over 2 h of cross linking timing but with the highest drug to polymer ratio 1:11. The optimum in vitro drug release was obvious upon decreasing drug to polymer ratio up to 1:09, resulting in 81.5% drug release over 24 h. In conclusion, micro spheres composed of gaur gum and sodium borate can delay and control the release of 5-fluorouracil over 24 h. Thus, further in vivo studies are suggested for final assessment. | URI: | https://open.uns.ac.rs/handle/123456789/2353 | ISSN: | 1011601X |
Nаlаzi sе u kоlеkciјаmа: | MDF Publikacije/Publications |
Prikаzаti cеlоkupаn zаpis stаvki
SCOPUSTM
Nаvоđеnjа
14
prоvеrеnо 09.09.2023.
Prеglеd/i stаnicа
24
Prоtеklа nеdеljа
10
10
Prоtеkli mеsеc
0
0
prоvеrеnо 10.05.2024.
Google ScholarTM
Prоvеritе
Stаvkе nа DSpace-u su zаštićеnе аutоrskim prаvimа, sа svim prаvimа zаdržаnim, оsim аkо nije drugačije naznačeno.